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KMID : 0043320080310101241
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Archives of Pharmacal Research
2008 Volume.31 No. 10 p.1241 ~ p.1246
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Microbial Metabolites of 8-Prenylnaringenin, an Estrogenic Prenylflavanone
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Lee Ik-Soo
Kang Bok-Yun
Kim Hyun-Jung
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Abstract
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Microbial metabolism studies of the phyto-estrogen (±)-8-prenylnaringenin (8-PN) (1) has led to the isolation of three pairs of metabolites (2-4). The structures of these compounds were identified as 5,4’- dihydroxy-7,8-[2-(1-hydroxy-1-methylethyl)-2,3-dihydrofurano]flavanones (2), 8-prenylnaringenin 7- O-β-D-glucopyranosides (3), and 8-prenylnaringenin 7-O-β-D-(6’’’-O-α-hydroxypropionyl)-glucopyranosides (4) on the basis of the spectroscopic analysis.
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KEYWORD
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Microbial metabolism, 8-Prenylnaringenin
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